I think Ramu should go for new casting with innovative concepet.
If he take the son and daughter of Amitabh, Dharmendra or Hema there is no new to see. But as per the tradition of Ramu factory he will definaltey go for new.
All the best to him and his excellent team.
For my point of view he shoud take main character as:
Amitabh- Abhishek Dharmendra- Saif Ali Khan Hema Malini- Rani Mukerji Jaya Bacchan- Tabu Thakur- Om puri Gabbar Singh- John Abraham Angreji POlice Officer- Johny Lever
Gabbar singh- k.k. Abhishek would play the role of amitabh Abhay deol should play the role of dharmendra ayesha takiya should play the role of hema malini vidya balan should play the role of jaya bhaduri